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Company ReportsMarinus Pharmaceuticals

Marinus Pharmaceuticals(MRNS)

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Trade Name	Drug Name	Approved	Patent Expires	Indication
Ztalmy	Ganaxolone	2023-07-26	2026-2037	Infantile spasms , Seizures , Epileptic syndromes

Clinical Trials

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Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

hyperlipoproteinemia type i

sleep wake disorders

,

,

addictive behavior

,

hepatic insufficiency

,

pick disease of the brain

,

,

,

pharmacokinetics

,

heart disease risk factors

,

vasoconstriction

,

migraine disorders

,

anxiety disorders

,

,

b-cell lymphoma

,

invasive hydatidiform mole

,

pharmacological phenomena

,

,

health behavior

,

primary progressive aphasia

,

,

electroencephalography

,

,

,

therapeutic equivalency

,

polycystic ovary syndrome

,

b-cell lymphoma marginal zone

,

,

diffuse intrinsic pontine glioma

,

,

,

breast carcinoma in situ

,

ductal carcinoma breast

,

intraductal carcinoma noninfiltrating

,

phenylketonurias

,

chronic progressive multiple sclerosis

,

noise-induced hearing loss

,

,

adult t-cell leukemia-lymphoma

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

,

persian gulf syndrome

,

endometrioid carcinoma

,

multiple system atrophy

,

parkinsonian disorders

,

,

progressive supranuclear palsy

,

iron-deficiency anemia

,

iron deficiencies

,

adrenocortical carcinoma

,

adrenal gland neoplasms

,

muscular dystrophies

,

corneal endothelial cell loss

,

,

gastrointestinal motility

,

psychotic affective disorders

,

mantle-cell lymphoma

,

dental pulp necrosis

,

asymptomatic diseases

,

,

bacterial infections

,

wound infection

,

prostheses and implants

,

prosthesis-related infections

,

,

,

,

,

myxoid liposarcoma

,

,

tooth extraction

,

,

chronic obstructive pulmonary disease

,

atopic dermatitis

,

,

myelodysplastic syndromes

,

non-hodgkin lymphoma

,

multiple myeloma

,

head and neck neoplasms

,

,

,

,

opioid-related disorders

,

bipolar disorder

,

obstructive lung diseases

,

obsessive-compulsive disorder

,

,

,

substance-related disorders

,

sleep initiation and maintenance disorders

,

cystic fibrosis

,

post-traumatic stress disorders

,

small cell lung carcinoma

,

,

,

,

triple negative breast neoplasms

,

squamous cell carcinoma of head and neck

,

respiration disorders

,

bronchiolitis obliterans syndrome

,

huntington disease

,

,

castration-resistant prostatic neoplasms

,

central nervous system diseases

,

nervous system diseases

,

central nervous system neoplasms

,

type 1 diabetes mellitus

,

,

plasma cell neoplasms

,

hematologic neoplasms

,

thyroid neoplasms

,

peripheral nervous system diseases

,

diabetic neuropathies

,

sensorineural hearing loss

,

biliary liver cirrhosis

,

,

movement disorders

,

medulloblastoma

,

,

rhabdomyosarcoma

,

,

,

large b-cell lymphoma diffuse

,

fallopian tube neoplasms

,

erectile dysfunction

,

,

critical illness

,

t-cell lymphoma

,

t-cell lymphoma peripheral

,

gastroesophageal reflux

,

vascular diseases

,

uterine cervical neoplasms

,

uterine cervical dysplasia

,

,

,

,

myelomonocytic leukemia chronic

,

myeloproliferative disorders

,

,

,

,

,

hereditary breast and ovarian cancer syndrome

,

neurodegenerative diseases

,

pheochromocytoma

,

,

insulin resistance

,

,

,

,

,

primitive neuroectodermal tumors peripheral

,

,

,

langerhans-cell histiocytosis

,

,

graft vs host disease

,

,

adenocarcinoma of lung

,

epstein-barr virus infections

,

,

platelet aggregation

,

large-cell lymphoma anaplastic

,

immunoblastic lymphadenopathy

,

enteropathy-associated t-cell lymphoma

,

optic nerve diseases

,

cerebrovascular disorders

,

glucose metabolism disorders

,

endocrine system diseases

,

,

,

,

,

cervical intraepithelial neoplasia

,

vulvar neoplasms

,

,

postherpetic neuralgia

,

atrial fibrillation

,

photochemotherapy

,

respiratory tract diseases

,

,

t-cell lymphoma cutaneous

,

,

,

combat disorders

,

myelomonocytic leukemia juvenile

,

urologic neoplasms

,

transitional cell carcinoma

,

merkel cell carcinoma

,

radical mastectomy

,

,

behavioral symptoms

,

hyperlipoproteinemia type i

,

hemophagocytic lymphohistiocytosis

,

,

gastrointestinal stromal tumors

,

,

chronic hepatitis c

,

pancreatic ductal carcinoma

,

stomach neoplasms

,

gastrointestinal neoplasms

,

digestive system neoplasms

,

biliary tract neoplasms

,

histiocytic sarcoma

,

juvenile xanthogranuloma

,

consciousness disorders

,

,

lymphoid leukemia

,

myelodysplastic-myeloproliferative diseases

,

hypertrophic pyloric stenosis

,

loss of heterozygosity

,

carcinoid tumor

,

serotonin syndrome

,

small cell carcinoma

,

neuroendocrine carcinoma

,

anaplastic thyroid carcinoma

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

familial dysautonomia

,

percutaneous coronary intervention

,

,

,

craniofacial abnormalities

,

,

optic nerve injuries

,

prediabetic state

,

oligodendroglioma

,

ventilator-associated pneumonia

,

pituitary acth hypersecretion

,

cushing syndrome

,

,

allergic rhinitis

,

,

lymphoproliferative disorders

,

cytomegalovirus infections

,

intrahepatic cholestasis

,

papillomavirus infections

,

vulvar diseases

,

,

idiopathic pulmonary fibrosis

,

cryptogenic organizing pneumonia

,

idiopathic interstitial pneumonias

,

hamman-rich syndrome

,

,

penile prosthesis

,

inferior wall myocardial infarction

,

alcohol-related disorders

,

peripheral blood stem cell transplantation

,

orthostatic hypotension

,

,

encephalomyelitis

,

biphenotypic leukemia acute

,

uveal neoplasms

,

,

lewy body disease

,

,

adolescent development

,

friedreich ataxia

,

out-of-hospital cardiac arrest

,

palliative care

,

iga glomerulonephritis

,

focal segmental glomerulosclerosis

,

intracranial vasospasm

,

congenital adrenal hyperplasia

,

adrenogenital syndrome

,

adrenocortical hyperfunction

,

alopecia areata

,

,

,

metabolic diseases

,

,

,

allergic conjunctivitis

,

,

complex partial epilepsy

,

bronchial diseases

,

,

st elevation myocardial infarction

,

non-st elevated myocardial infarction

,

reflex epilepsy

,

hematopoietic stem cell transplantation

,

neurologic manifestations

,

,

fragile x syndrome

,

squamous intraepithelial lesions

,

drug-induced dyskinesia

,

atherosclerosis

,

,

alcohol drinking

,

traumatic stress disorders

,

thrombocytopenia

,

acquired immunodeficiency syndrome

,

aids dementia complex

,

foot deformities

,

congenital foot deformities

,

group psychotherapy

,

,

nasopharyngeal carcinoma

,

nasopharyngeal neoplasms

,

,

,

post-head injury coma

,

,

,

,

myeloid leukemia acute

,

,

,

overactive urinary bladder

,

basal cell neoplasms

,

,

,

bcr-abl positive chronic myelogenous leukemia

,

squamous cell carcinoma

,

,

,

diabetic nephropathies

,

,

traumatic brain injuries

,

acute coronary syndrome

,

myeloid leukemia

,

b-cell chronic lymphocytic leukemia

,

,

,

liver cirrhosis

,

,

autoimmune diseases of the nervous system

,

squamous cell neoplasms

,

,

,

chronic hepatitis b

,

chronic hepatitis

,

esophageal neoplasms

,

local anesthesia

,

follicular lymphoma

,

,

neurotoxicity syndromes

,

amyotrophic lateral sclerosis

,

motor neuron disease

,

autistic disorder

,

autosomal dominant polycystic kidney

,

mitral valve insufficiency

,

knee osteoarthritis

,

endometrial neoplasms

,

hyperlipidemias

,

,

hematologic diseases

,

urologic diseases

,

precursor cell lymphoblastic leukemia-lymphoma

,

exfoliation syndrome

,

,

,

pulmonary arterial hypertension

,

,

,

anti-n-methyl-d-aspartate receptor encephalitis

,

aortic valve insufficiency

,

philadelphia chromosome

,

,

prostatic hyperplasia

,

,

,

,

,

,

metabolic syndrome

,

end stage liver disease

,

,

carcinoma in situ

,

,

,

,

,

spinal cord injuries

,

tibial fractures

,

hereditary nephritis

,

status epilepticus

,

gastrointestinal diseases

,

,

attention deficit disorder with hyperactivity

,

myofascial pain syndromes

,

,

,

cutaneous leishmaniasis

,

,

,

,

pathologic processes

,

lupus nephritis

,

,

myeloid leukemia chronic-phase

,

bone marrow diseases

,

lower urinary tract symptoms

,

ocular hypertension

,

coronavirus infections

,

,

child development

,

,

diabetic retinopathy

,

,

neurosurgical procedures

,

,

pervasive child development disorders

,

granulomatosis with polyangiitis

,

microscopic polyangiitis

,

fluoride poisoning

,

human influenza

,

cerebral arterial diseases

,

musculoskeletal diseases

,

,

,

drug hypersensitivity

,

newborn infant diseases

,

,

sjogren's syndrome

,

,

drug resistant epilepsy

,

anterior wall myocardial infarction

,

hodgkin disease

,

neuromuscular junction diseases

,

musculoskeletal pain

,

,

sensation disorders

,

reactive arthritis

,

,

,

healthy volunteers/patients

,

major depressive disorder

,

,

postoperative pain

,

emergence delirium

,

,

general anesthesia

,

prostatic neoplasms

,

,

breast neoplasms

,

actinic keratosis

,

type 2 diabetes mellitus

,

,

cognitive dysfunction

,

,

,

depressive disorder

,

pancreatic neoplasms

,

,

respiratory aspiration

,

intravenous anesthesia

,

,

,

brain neoplasms

,

postoperative cognitive complications

,

coronary artery disease

,

parkinson disease

,

diabetes mellitus

,

basal cell carcinoma

,

postoperative nausea and vomiting

,

colorectal neoplasms

,

,

wounds and injuries

,

alzheimer disease

,

,

cardiovascular diseases

,

,

drug-related side effects and adverse reactions

,

,

psychomotor agitation

,

,

,

inhalation anesthesia

,

,

,

chronic renal insufficiency

,

renal insufficiency

,

,

,

postoperative complications

,

,

colonic neoplasms

,

,

,

respiratory distress syndrome

,

reperfusion injury

,

neoplasm metastasis

,

non-small-cell lung carcinoma

,

,

,

,

,

,

ovarian neoplasms

,

inguinal hernia

,

non-alcoholic fatty liver disease

,

rheumatoid arthritis

,

coronary artery bypass

,

,

congenital heart defects

,

,

,

,

treatment-resistant depressive disorder

,

anesthesia recovery period

,

cardiac surgical procedures

,

cognition disorders

,

liver neoplasms

,

psychotic disorders

,

,

acute kidney injury

,

,

renal cell carcinoma

,

rectal neoplasms

,

respiratory tract infections

,

,

,

myocardial infarction

,

,

,

bowen's disease

,

,

acute lung injury

,

hepatocellular carcinoma

,

coronary disease

,

myocardial ischemia

,

pulmonary hypertension

,

,

,

anesthesia and analgesia

,

,

,

,

systemic lupus erythematosus

,

delayed emergence from anesthesia

,

irritable bowel syndrome

,

neuroinflammatory diseases

,

kidney diseases

,

inflammatory bowel diseases

,

,

ulcerative colitis

,

bariatric surgery

,

kidney transplantation

,

cesarean section

,

,

sleep apnea syndromes

,

,

communicable diseases

,

drug interactions

,

,

intraoperative awareness

,

myocardial reperfusion injury

,

intracranial aneurysm

,

muscle relaxation

,

oxidative stress

,

,

,

subarachnoid hemorrhage

,

,

suicidal ideation

,

neurocognitive disorders

,

,

circulating neoplastic cells

,

newborn respiratory distress syndrome

,

laryngeal masks

,

chronic kidney failure

,

hypercholesterolemia

,

laparoscopic cholecystectomy

,

ovarian epithelial carcinoma

,

postoperative period

,

obstructive sleep apnea

,

,

unconsciousness

,

kidney neoplasms

,

,

,

neurodevelopmental disorders

,

,

memory disorders

,

male breast neoplasms

,

multiple sclerosis

,

,

,

,

thoracic surgical procedures

,

,

pituitary neoplasms

,

,

pituitary diseases

,

disease progression

,

,

,

chronic fatigue syndrome

,

diabetes complications

,

ultrasonography

,

,

,

respiratory insufficiency

,

angina pectoris

,

unstable angina

,

urge urinary incontinence

,

carotid stenosis

,

,

,

,

muscle hypotonia

,

,

ambulatory surgical procedures

,

,

,

,

,

off-pump coronary artery bypass

,

abdominal aortic aneurysm

,

,

nociceptive pain

,

interstitial lung diseases

,

surgical wound infection

,

aortic valve stenosis

,

airway extubation

,

liver transplantation

,

,

airway management

,

biliary atresia

,

heart valve diseases

,

aortic diseases

,

aortic aneurysm

,

premature birth

,

,

pain measurement

,

,

postpartum hemorrhage

,

mental disorders

,

,

,

,

dentin sensitivity

,

,

,

magnetic resonance imaging

,

morphine dependence

,

helicobacter infections

,

,

,

,

post-dural puncture headache

,

rotator cuff injuries

,

,

,

spinal anesthesia

,

intestinal pseudo-obstruction

,

closed fractures

,

,

graft rejection

,

,

urologic surgical procedures

,

female genital diseases

,

fetal nutrition disorders

,

neurofibromatoses

,

abdominal neoplasms

,

,

substance-induced psychoses

,

,

,

,

enzyme induction

,

allergic rhinitis seasonal

,

energy metabolism

,

,

extrinsic allergic alveolitis

,

multiple organ failure

,

visceral leishmaniasis

,

subdural hematoma

,

,

subdural hematoma acute

,

ventricular dysfunction

,

,

,

respiratory system abnormalities

,

microcirculation

,

cholangiocarcinoma

,

gallbladder neoplasms

,

respiratory aspiration of gastric contents

,

,

aortic dissection

,

vaginal diseases

,

,

ureteral obstruction

,

vascular surgical procedures

,

genomic instability

,

problem behavior

,

,

,

delayed graft function

,

,

endotracheal anesthesia

,

conduction anesthesia

,

arteriosclerosis

,

arteriosclerosis obliterans

,

retinal diseases

,

retinopathy of prematurity

,

pneumoperitoneum

,

electroconvulsive therapy

,

,

,

uterine inertia

,

connective tissue diseases

,

schizophrenia spectrum and other psychotic disorders

,

hearing disorders

,

central auditory diseases

,

,

motor evoked potentials

,

,

,

,

,

renal hypertension

,

occupational diseases

,

hypoventilation

,

,

,

procedural pain

,

,

intra-articular injections

,

,

renal circulation

,

gynecologic surgical procedures

,

video-assisted thoracic surgery

,

dry eye syndromes

,

,

,

urinary bladder neoplasms

,

deglutition disorders

,

,

trigger finger disorder

,

surgical blood loss

,

,

transurethral resection of prostate

,

,

operative surgical procedures

,

mitochondrial diseases

,

cardiopulmonary bypass

,

intratracheal intubation

,

,

open-angle glaucoma

,

minimally invasive surgical procedures

,

intestinal diseases

,

neurobehavioral manifestations

,

hyperhomocysteinemia

,

,

,

intraocular pressure

,

,

,

cocaine-related disorders

,

hypersensitivity

,

pulmonary embolism

,

,

,

physiological sexual dysfunction

,

viral pneumonia

,

spinal diseases

,

,

,

tobacco use disorder

,

intracranial pressure

,

,

femoral fractures

,

,

severe acute respiratory syndrome

,

immunosuppression therapy

,

,

,

impulsive behavior

,

,

enhanced recovery after surgery

,

inert gas narcosis

,

immunologic cytotoxicity

,

ventricular tachycardia

,

,

feeding and eating disorders

,

bulimia nervosa

,

,

chronic traumatic encephalopathy

,

vitamin b 12 deficiency

,

,

glucose intolerance

,

relapsing-remitting multiple sclerosis

,

bacterial vaginosis

,

,

,

dentofacial deformities

,

thrombocytopenic purpura idiopathic

,

escherichia coli infections

,

mental competency

,

cerebrovascular circulation

,

,

,

thoracic aortic aneurysm

,

,

one-lung ventilation

,

supratentorial neoplasms

,

,

caudal anesthesia

,

,

,

breast implantation

,

pupil disorders

,

frontotemporal dementia

,

,

folic acid deficiency

,

psychological distress

,

complete denture

,

eosinophilic esophagitis

,

,

,

liver function tests

,

robotic surgical procedures

,

,

hemiarthroplasty

,

acquired ear deformities

,

endophthalmitis

,

,

,

soft tissue injuries

,

vascular system injuries

,

ischemic optic neuropathy

,

,

,

,

,

hemifacial spasm

,

cerebral infarction

,

mobility limitation

,

,

,

,

vitreous detachment

,

cataract extraction

,

pulmonary ventilation

,

dna methylation

,

psychology unconscious

,

uterine neoplasms

,

,

periodontal diseases

,

gingival diseases

,

endoplasmic reticulum stress

,

left ventricular dysfunction

,

blood transfusion

,

premature infant diseases

,

cardiovascular surgical procedures

,

,

lymphocyte depletion

,

,

moyamoya disease

,

consciousness monitors

,

induced hypothermia

,

,

retinal detachment

,

vitreous hemorrhage

,

rotator cuff tear arthropathy

,

laryngeal nerve injuries

,

,

induced abortion

,

dilatation and curettage

,

,

,

,

denture stomatitis

,

learning disabilities

,

alcoholic liver diseases

,

,

intervertebral disc degeneration

,

brain concussion

,

embolism and thrombosis

,

,

sickle cell anemia

,

,

paraneoplastic syndromes

,

muscle weakness

,

,

,

,

burning mouth syndrome

,

,

nonketotic hyperglycinemia

,

,

,

,

,

spinal fractures

,

chronic disease

,

aphthous stomatitis

,

diabetes insipidus

,

nephrogenic diabetes insipidus

,

nephrolithiasis

,

,

,

ureteral calculi

,

ureteral diseases

,

neurophysiological monitoring

,

lacrimal duct obstruction

,

dacryocystorhinostomy

,

congenital hip dislocation

,

hip dislocation

,

developmental dysplasia of the hip

,

somatoform disorders

,

dissociative disorders

,

malignant hyperthermia

,

,

visual evoked potentials

,

,

,

replacement arthroplasty knee

,

periodontal pocket

,

noncommunicable diseases

,

,

radiodermatitis

,

thoracic injuries

,

noninvasive ventilation

,

multiple chronic conditions

,

,

,

body temperature changes

,

,

,

sleep deprivation

,

,

transcranial magnetic stimulation

,

autoimmune diseases

,

pelvic organ prolapse

,

stress urinary incontinence

,

,

,

,

,

cognitive reserve

,

spinal stenosis

,

,

,

,

respiratory syncytial virus infections

,

,

,

pulmonary atelectasis

,

aggressive periodontitis

,

alveolar ridge augmentation

,

,

,

rheumatic diseases

,

pain management

,

gastrointestinal endoscopy

,

intraoperative monitoring

,

respiratory mechanics

,

cigarette smoking

,

percutaneous nephrolithotomy

,

gingival hemorrhage

,

patient reported outcome measures

,

,

,

female infertility

,

acoustic neuroma

,

microvascular decompression surgery

,

,

hypertriglyceridemia

,

,

food diet and nutrition

,

,

neuronal plasticity

hyperlipoproteinemia type i

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